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Users share brutal side effect known as ‘Ozempic poo’ leaving people horrified

Home> Science> News

Updated 10:41 1 Dec 2025 GMTPublished 10:16 1 Dec 2025 GMT

Users share brutal side effect known as ‘Ozempic poo’ leaving people horrified

Better keep the bathroom handy

Tom Chapman

Tom Chapman

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Featured Image Credit: Peter Dazeley / Contributor via Getty
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There are more alarming reports about why you might want to think twice about taking Ozempic and other so-called 'skinny jabs', and as you might've guessed from the name, 'Ozempic poo' isn't exactly a pleasant one.

A number of weird and wonderful side effects have been connected to glucagon-like peptide-1 (GLP-1) injections, with the likes of 'Ozempic penis' and 'Ozempic teeth' doing exactly what they say on the tin.

Unfortunately for some, Ozempic poo doesn't miraculously turn your deposits into little piles of gold. With President Donald Trump ushering in a new era of weight loss drugs as prices tumble and alternatives multiply, the popularity of these jabs continues to soar.

Still, while there's plenty of talk about supposed benefits like the potential to reverse signs of liver damage, other studies have linked it to pancreatitis and more.

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We've heard of sh*tting the bed in terms of not having the confidence to do something, but apparently, Ozempic poo is taking that quite literally.

'Ozempic poo' isn't anything any of us want to experience (Tatiana Meteleva / Getty)
'Ozempic poo' isn't anything any of us want to experience (Tatiana Meteleva / Getty)

Over on Reddit, one concerned jabber wrote: "Any advice for not sh*tting in the bed while sleep?"

In the thread, the OP stated that they've been struggling with this problem for the past few months and branded it 'the most annoying side effect.' Yeah, no sh*t, Sherlock.

Others in the thread were equally worried, as one person said: "That’s an extreme side effect. You should talk to your doctor.

“Do not eat any greasy foods or complicated carbohydrates. Eat small amounts. Don’t eat after seven. You can become extremely dehydrated. Good luck."

Someone else added: "This week was my third shot. Things I’m looking forward to: 1. Lowering my A1C. Second week on this subreddit. Things I’m not looking forward to: 1. Having my hair fall out. 2. Sh*tting the bed. In no particular order."

Alongside one person suggesting diapers, others shared the opposite effect and said they've been suffering from constipation since injecting themselves. A third concluded: "Yeah I’m sh*tting rocks so I can’t relate 😂."

Wegovy's prescription information claims that 30% of users in clinical trials experienced diarrhea, with 24% suffering from constipation. Either way, the idea of following through in the middle of the night doesn't exactly have us rushing out to buy pens.



Taking to TikTok, weight loss doctor Dr. Daniel Rosen suggested that Ozempic poo might be caused by your body’s alert system: “When you eat a large meal, there's something called the gastrocolic reflex, where the stretch in the top of the stomach alerts the very end of the colon and rectum to empty."

He went on to say that GLP-1 medications like Ozempic and Wegovy can "trick your brain into thinking that food has arrived to the end of the intestines."

Speaking to LADBible Group, Novo Nordisk shared the following statement: "Gastrointestinal (GI) events are well-known side effects of the GLP-1RA class. For semaglutide, the majority of GI side effects are mild to moderate in severity and of short duration.

"GLP-1’s are known to cause a delay in gastric emptying, as noted in the label of each of our GLP-1 RA medications. Symptoms of delayed gastric emptying, nausea and vomiting are listed as side effects.

"Novo Nordisk recommends patients take these medications for their approved indications and under the supervision of a healthcare professional. Patient safety is of utmost importance to Novo Nordisk.

"We recommend that any patients experiencing side effects while taking Novo Nordisk GLP receptor agonists report them to their healthcare provider and via the MHRA Yellow Card scheme: https://yellowcard.mhra.gov.uk/. Adverse events should also be reported to Novo Nordisk via the Customer Care Centre by calling 0800 023 2573."

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