The popularity of so-called skinny jabs shows no sign of slowing down, and as the festive season is upon us, offering turkey with all the trimmings, slices of pie, and one too many chocolates, you might be thinking about embarking on your fitness journey in January 2026.
New Year's resolutions are just over the horizon, so expect gym memberships to soar.
For those who don’t want to try training like a professional athlete, the likes of Ozempic and Wegovy can offer an alternative.
Despite concerns about side effects like pancreatitis, a potential mental health crisis, and more obscure ones like 'Ozempic vagina', GLP-1 injections are still all the rage.
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They also come with proposed pros like the potential to reverse liver damage and cardiovascular benefits, meaning Ozempic and the rest arguably have as many supporters as critics.
The World Health Organization made a spectacular U-turn on them, while President Donald Trump has tried to bring down prices in a bid to make them more accessible for more people.
With a new pill form potentially on the way as early as next year, we expect the popularity of these drugs to spike once again.
We've already been warned that there are certain foods you should avoid if you're injecting semaglutides this Christmas, but if you watch the latest simulation from Zack D. Films, we're not sure you'll be particularly hungry anyway.
Having shown us exactly how Ozempic works inside your body, Zack D. Films is back with another video that might be a little much for some of you to 'stomach'.
The simulation explains that once you inject Ozempic, it activates the receptors in your brain linked to hunger. Acting as a GLP-1 receptor agonist to regulate blood sugar and your appetite, these injections tell your pancreas to release more insulin and less glucagon while slowing your stomach emptying. Your brain is also signaled to say you're full, and by eating less, the idea is that you'll lose weight more quickly.
With your blood sugar stabilized, you're also less likely to reach for those sugary snacks.
Into the warning part of the video, Jack D. Films reminds us that some people tend to feel sick while taking these drugs. There's also a possible unpleasant side effect of diarrhea, which some have nicknamed 'Ozempic poo'.
Responding to the video, one person said: "Zack i am currently eating chocolate and that last part made me lose my cravings, thank you for working better than an Ozempic."
Another added: "Man i was thinking about using it but that last part thanks Zack🙁."
A third grimaced: "Tbh, watching Zack’s animations make me lose my appetite more than Ozempic 😭."
While it's all well and good being able to slip into that outfit you've been saving since last New Year's Eve, there are obvious concerns about toilet troubles.
Noro Nordisk has previously spoken out about these side effects, telling LADBible Group: "Gastrointestinal (GI) events are well-known side effects of the GLP-1RA class. For semaglutide, the majority of GI side effects are mild to moderate in severity and of short duration.
"GLP-1’s are known to cause a delay in gastric emptying, as noted in the label of each of our GLP-1 RA medications. Symptoms of delayed gastric emptying, nausea and vomiting are listed as side effects.
"Novo Nordisk recommends patients take these medications for their approved indications and under the supervision of a healthcare professional. Patient safety is of utmost importance to Novo Nordisk.
"We recommend that any patients experiencing side effects while taking Novo Nordisk GLP receptor agonists report them to their healthcare provider and via the MHRA Yellow Card scheme: https://yellowcard.mhra.gov.uk/. Adverse events should also be reported to Novo Nordisk via the Customer Care Centre by calling 0800 023 2573."